Comments on: Common Blind Spot: Intramolecular Reactions https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/ Thu, 09 Feb 2023 05:41:43 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: A https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-647672 Thu, 09 Feb 2023 05:41:43 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-647672 Oh right. Thanks for answering.

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-647650 Wed, 08 Feb 2023 22:36:17 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-647650 In reply to A.

The acid-base reaction is an equilibrium. So long as the difference in pKa values is less than 10 or so, there will be a meaningful concentration of the less stable conjugate base, and that can then participate in reactions.

]]> By: A https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-647634 Wed, 08 Feb 2023 18:09:24 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-647634 excuse me but I have a doubt, the cyclic ether reaction is still confusing me a bit because there’s the reagent NaOH and 4-bromobutanol, so to get the butoxide nucleophile I guess the OH- would take off the H from the butanol? But 4-bromobutoxide is a stronger base than OH- [a website said that pKa of 4 bromobutanol is 14.98±0.10(Predicted)], so how would that acid-base reaction occur? This is more a question about Williamson ether synthesis I guess.

]]> By: Sourav https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-572657 Sun, 08 Dec 2019 01:06:48 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-572657 Can you please tell me if there will be ring formation in case of a molecule where the nucleophile and electrophile are at the ends of a very long aklyl chain?

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-555289 Wed, 15 May 2019 02:42:44 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-555289 In reply to Thomas Luedeke.

“Give me a bunch of rings all stuck together, and I crumple into the fetal position crying for my Mommy.”
This has my vote as favorite comment of all time. Thank you Thomas

]]> By: Anurag https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-446668 Mon, 08 Feb 2016 03:24:09 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-446668 U r best. Thanks lord for creating humans like u. It explanations and creativeness are just WOW!!

]]> By: Thomas Luedeke https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-397683 Tue, 19 May 2015 05:28:33 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-397683 I despise intramolecular reactions with a white hot passion, particularly when it comes to retrosynthetic analysis. Give me a bunch of rings all stuck together, and I crumple into the fetal position crying for my Mommy. No idea how to tackle them. Generally no idea on what the linking sites on precursors are, or how to systematically approach problems.

IMHO, it is barely taught at all in organic classes. Most books seem to barely mention intramolecular reactions, let alone scrutinize it as a troublesome area for students. And when it is taught, it isn’t taught very well. Frequently it just seems to pop upon tests for the purposes of destroying students.

The lack of emphasis on this topic seems utterly bizarre to me considering how incredibly important it is in chemical synthesis and in biochemistry.

]]> By: Oskar Henriksson https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-308324 Sat, 04 Oct 2014 09:03:24 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-308324 Maybe you should mention something about why these reactions usually are favoured kinetically?

]]> By: ntakirutimana emmanuel https://www.masterorganicchemistry.com/2011/07/04/common-blind-spot-intramolecular-reactions/#comment-13517 Thu, 03 Jan 2013 07:46:57 +0000 https://www.masterorganicchemistry.com/?p=1664#comment-13517 very interesting to get this web,i am a science teacher at blind school,some times it is very difficult to me to teach my students .big up!!

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