Comments on: Decarboxylation https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/ Mon, 19 Feb 2024 07:44:58 +0000 hourly 1 https://wordpress.org/?v=6.6.2 By: 5 Easy Steps to Decarboxylate Your Weed - flowerz™ https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/#comment-685325 Mon, 19 Feb 2024 07:44:58 +0000 https://www.masterorganicchemistry.com/?p=25990#comment-685325 […] (pronounced de-carb-OX-yl-a-tion) is a very sciencey-sounding word for a relatively simple process. Decarboxylation is the process that activates the […]

]]> By: Everything You Need to Know About THCA Flower : Woman of Many Roles https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/#comment-664275 Wed, 26 Jul 2023 22:19:48 +0000 https://www.masterorganicchemistry.com/?p=25990#comment-664275 […] the compound doesn’t produce psychoactive effects in its raw form is essential. THCA must be decarboxylated through heat application to convert into THC, which can bind to your body’s endocannabinoid […]

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/#comment-660950 Fri, 07 Jul 2023 20:52:09 +0000 https://www.masterorganicchemistry.com/?p=25990#comment-660950 In reply to Mikel Do.

Hi – yes, that’s a typo! Should be “azide” not “acide” :-)

]]> By: Mikel Do https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/#comment-660931 Fri, 07 Jul 2023 17:15:44 +0000 https://www.masterorganicchemistry.com/?p=25990#comment-660931 Hello!
In §8 you discuss a Curtius rearrangement in which an acyl azide is heated and rearranged into an isocyanate, losing N2 in the process.
However, in the corresponding diagram, you draw a molecule subtitled “Acyl acid”… Is this an oversight or is there another explanation?

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/#comment-654499 Mon, 08 May 2023 11:47:29 +0000 https://www.masterorganicchemistry.com/?p=25990#comment-654499 In reply to Deepak Thakur.

Depends on structure, but at the end of it, there are lots of mild room-temperature protocols for basic ester hydrolysis (LiOH, H2O/THF) that will give you the carboxylic acid at the end. Acidic hydrolysis generally involves heat and with heat comes decarboxylation.

]]> By: Deepak Thakur https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/#comment-654478 Mon, 08 May 2023 06:22:02 +0000 https://www.masterorganicchemistry.com/?p=25990#comment-654478 Let’s say I plan out a synthesis that involves the formation of beta keto carboxylic acid as a product (like in Doebner modification of Knoevenagel condensation), what are the methods to make sure that this acid doesn’t decarboxylate? Will low temperature (like room temperature) do the trick? Or will I need to choose a specific solvent system?

]]> By: 5 Easy Steps to Decarboxylate Your Weed - flowerz https://www.masterorganicchemistry.com/2022/05/20/decarboxylation/#comment-649288 Thu, 02 Mar 2023 17:31:12 +0000 https://www.masterorganicchemistry.com/?p=25990#comment-649288 […] (pronounced de-carb-OX-yl-a-tion) is a very sciencey-sounding word for a relatively simple process. Decarboxylation is the process that activates the […]

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